Como fornecedor líder de 2-Bromohexanoato de Metila, fornecemos produtos de alta qualidade em diversos graus para atender às necessidades em evolução, capacitando clientes globais com soluções químicas seguras, eficientes e compatíveis.
What are the chemical properties of Methyl 2-Bromohexanoate?
Metil 2 - Bromohexanoato também é um composto orgânico. Suas propriedades químicas são muito interessantes, deixe-me explicar em detalhes para você.
Este composto contém átomos de bromo e grupos ésteres, ambos os quais são grupos funcionais chave. Os átomos de bromo são ativos e muitas vezes podem iniciar reações de substituição. Como a eletronegatividade dos átomos de bromo é bastante alta, o carbono conectado a eles é parcialmente carregado positivamente e fácil de ser atacado por nucleófilos. No caso de hidroxila, amino e outros nucleófilos, os átomos de bromo podem ser substituídos, resultando na geração de muitos novos compostos.
Além disso, os grupos ésteres não são ociosos. Sob condições ácidas ou básicas, podem ocorrer reações de hidrólise. Em meios ácidos, a reação de hidrólise é reversível, resultando em ácido 2-bromohexanóico e metanol; em ambientes alcalinos, a reação de hidrólise é irreversível, resultando em 2-bromohexanoato e metanol.
Além disso, o alfa-hidrogênio do 2-Bromohexanoato de metila é afetado por grupos éster e átomos de bromo, e tem uma certa acidez. Pode ser retirado sob a ação de bases fortes, que por sua vez desencadeia reações como condensação, ampliando sua aplicação no campo da síntese orgânica.
E devido à presença de cadeias de carbono em sua estrutura, pode participar de algumas reações relacionadas às cadeias de carbono. Por exemplo, sob certas condições, a cadeia de carbono pode ser aumentada ou encurtada, proporcionando ricas possibilidades de síntese orgânica. As várias propriedades químicas deste composto o tornam um papel indispensável na etapa da química orgânica sintética.
What are the synthesis methods of Methyl 2-Bromohexanoate?
There are several common methods for preparing methyl 2-bromohexanoate.
First, 2-hexanoic acid is reacted with brominating reagents and methanol. 2-hexanoic acid is first reacted with brominating reagents such as phosphorus tribromide ($PBr_ {3} $) or a mixture of hydrobromic acid and sulfuric acid. The hydroxyl group of the carboxyl group is replaced by bromine to obtain 2-bromohexanoic acid. Then 2-bromohexanoic acid and methanol are esterified under acid catalysis. Sulfuric acid and p-toluenesulfonic acid are commonly used in acid catalysis. During this process, the carboxyl group of 2-bromohexanoic acid and the hydroxyl group of methanol are dehydrated and condensed to form methyl 2-bromohexanoate and water. The reaction formula is roughly: $C_ {5} H_ {11} COOH + PBr_ {3}\ longrightarrow C_ {5} H_ {11} COBr + H_ {3} PO_ {3} $, $C_ {5} H_ {11} COBr + CH_ {3} OH\ xrightarrow {H ^ {+}} C_ {5} H_ {11} COOCH_ {3} + HBr $.
Second, it can be started from caprolactone. Caprolactone first undergoes a ring-opening reaction, such as reacting with methanol under basic conditions, so that the lactone ring is opened to obtain a hydroxyl esteride. The hydroxyl group is then replaced with bromine. For example, the reaction of caprolactone with methanol is catalyzed by a base (such as sodium hydroxide): $C_ {6} H_ {10} O_ {2} + CH_ {3} OH\ xrightarrow {OH ^ {-}} CH_ {3} O (CH_ {2}) _ {5} COOH $. The obtained product interacts with a brominating agent such as phosphorus tribromide, and the hydroxyl group is replaced by bromine to obtain methyl 2-bromohexanoate.
Third, starting from 2-bromohexanonitrile. 2-Bromohexanonitrile is first hydrolyzed to obtain 2-bromohexanoic acid, and the hydrolysis is generally carried out under acidic or alkaline conditions. Strong acids such as sulfuric acid are commonly used for acidic hydrolysis, and strong bases such as sodium hydroxide are commonly used for alkaline hydrolysis. Then 2-bromohexanoic acid is esterified with methanol under acid catalysis to form the target product methyl 2-bromohexanoate. For example, the basic hydrolysis reaction formula: $C_ {5} H_ {10} BrCN + 2H_ {2} O + NaOH\ longrightarrow C_ {5} H_ {10} BrCOONa + NH_ {3}\ cdot H_ {2} O $, acidified to obtain 2-bromohexanoic acid, and then esterified with methanol
What are the applications of Methyl 2-Bromohexanoate in organic synthesis?
Methyl-2-bromohexanoate has a wide range of uses in organic synthesis.
First, it can be used for nucleophilic substitution reactions. Because it contains bromine atoms, its activity is quite high, and it is easy to be attacked by nucleophilic reagents. Bromine ions leave, thus introducing other groups. For example, by reacting with alcohol nucleophilic reagents, ester derivatives can be formed, which is valuable in the construction of complex ester structures.
Second, it also has important applications in the field of metal-organic chemistry. Reacting with metal reagents, such as magnesium and zinc, can generate organometallic reagents. Taking Grignard reagent as an example, the Grignard reagent formed by the interaction of methyl-2-bromohexanoate with magnesium can undergo addition reaction with carbonyl compounds such as aldodes and ketones, and then prepare various alcohols. It is an extremely critical means in the process of forming carbon-carbon bonds.
Third, it plays a significant role in the construction of carbon-heteroatom bonds. Reacting with nucleophiles containing heteroatoms such as nitrogen, oxygen, and sulfur can prepare compounds containing corresponding heteroatoms. If reacting with amines, amide compounds can be formed, which play an important role in many fields such as drug synthesis and materials science.
Furthermore, it can participate in the elimination reaction. Under certain conditions, the elimination of hydrogen bromide and the formation of double bonds provide an effective path for the synthesis of compounds containing ethylene bonds. As active functional groups, ethylene bonds can further undergo many reactions and expand the types and structures of compounds.
In summary, methyl-2-bromohexanoate, with its unique structure and active properties, provides rich strategies and possibilities for the preparation of various organic compounds in the process of organic synthesis.
What are the storage conditions for Methyl 2-Bromohexanoate?
For methyl 2-bromohexanoate, the storage conditions are related to the stability of its quality and the effectiveness of its use, which cannot be ignored. This agent should be placed in a cool, dry and well-ventilated place. If it is cool, avoid the high temperature environment. If it is exposed to high temperature, or it may cause its chemical properties to change, there is a risk of decomposition and damage to its pure quality. Drying is also important. If it is wet, it is easy for water vapor to respond, or it may cause changes in hydrolysis, change its structure, and lose its original use. Well-ventilated, it can dissipate harmful gas, and avoid accumulation and danger.
And it must be kept away from fire and heat sources to prevent the danger of explosion. This agent is exposed to open flames, hot topics, or the risk of fire and combustion, so in the storage place, no fireworks, control the heat source, and strictly control the power equipment to prevent it from igniting and generating heat.
And it is appropriate to store it separately from oxidizing agents and alkalis. Oxidizing agents can promote its oxidation, and alkalis can lead to its hydrolysis, which will harm its quality. Separate storage, to keep their own characteristics, so as not to interfere with each other and change.
Receptacles should also be selected carefully, and sealed devices should be used to keep air and water vapor away. Glass or metal devices, if they are well airtight, can be used. Check their devices in storage to prevent leakage. Leakage will cause the agent to dissipate, which will not only lose its use, but also pollute the environment and harm people and animals. Only in this way can the quality of methyl 2-bromohexanoate be retained for timely use.
What are the safety precautions for Methyl 2-Bromohexanoate?
Methyl 2-bromohexanoate, an organic compound, is concerned with its safety precautions. Let me explain in detail.
Methyl 2-bromohexanoate is irritating and can come into contact with the skin, eyes, or cause discomfort or damage. When operating, be sure to wear protective equipment, such as gloves, goggles, and lab clothes to prevent direct contact. If you accidentally come into contact with the skin, you should immediately rinse with plenty of water, and then seek medical attention. If you splash into the eyes, you need to rinse quickly with plenty of water, and seek medical help as soon as possible.
When this compound is heated or burned, it will release toxic fumes and harmful gases such as hydrogen bromide. Therefore, the operation should be carried out in a well-ventilated place, such as a fume hood, to ensure that harmful gases are discharged in time and will not endanger the operator.
It is a flammable substance, which may cause combustion and explosion in case of open flame, hot topic or strong oxidant. The storage place must be kept away from the fire, heat source, and stored separately from the oxidant. It must not be mixed and stored. At the same time, suitable fire fighting equipment should be prepared.
Furthermore, methyl 2-bromohexanoate is a chemical substance. After use, the residue and waste must not be discarded at will. It should follow relevant regulations and be properly disposed of to prevent pollution to the environment.
In conclusion, when using methyl 2-bromohexanoate, it is necessary to strictly follow the safety operating procedures, always pay attention to personal protection and environmental protection, and must not be taken lightly.